Resources | Health News | Therapies | Fitness
H2 Blockers - Interactions and Warnings
- J Lab Clin Med 1988 Oct;112(4):458-63 -- Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. -- Russell RM, Golner BB, Krasinski SD, Sadowski JA, Suter PM, Braun CL.
Cimetidine is known to interfere with other drugs through hepatic metabolism, the concentration of co-committant drugs such as warfarin, benzodiazepine tend to be elevated. Cimetidine should be replaced by the other H2RAs which have no such effects.
- Nippon Rinsho 2002 Aug;60(8):1613-7 -- What is important in treating elderly with H2 receptor antagonists -- Kurosawa S.
Cimetidine administration did not lead to malabsorption of unbound cobalamin but caused malabsorption of protein-bound cobalamin. Patients on cimetidine therapy malabsorb protein-bound cobalamin and, during long-term treatment, are at risk for developing cobalamin deficiency.
- Dig Dis Sci 1980 Mar;25(3):188-91 -- Malabsorption of protein-bound cobalamin but not unbound cobalamin during cimetidine administration. -- Steinberg WM, King CE, Toskes PP.
The use of H(2)-receptor antagonists and/or PPIs may impair the absorption of protein-bound dietary vitamin B(12) and could contribute to the development of vitamin B(12) deficiency with prolonged use. Patients taking these medications for extended periods of time, particularly >4 years, should be monitored for vitamin B(12) status.
- Ann Pharmacother 2002 May;36(5):812-6 -- Vitamin B(12) deficiency associated with histamine(2)-receptor antagonists and a proton-pump inhibitor. -- Ruscin JM, Page RL, Valuck RJ.
Gastric acid secretion has been demonstrated to facilitate iron absorption. Zinc absorption was reduced after cimetidine administration. Suggests that gastric acid secretion plays a role in the regulation of zinc absorption.
- J Am Coll Nutr 1991 Aug;10(4):372-5 -- Inhibition of gastric acid secretion reduces zinc absorption in man. -- Sturniolo GC, Montino MC, Rossetto L, Martin A, D'Inca R, D'Odorico A, Naccarato R.
Vitamin D absorption may be affected.
- J Lab Clin Med 1984 Oct;104(4):546-52 -- Hepatic vitamin D 25-hydroxylase inhibition by cimetidine and isoniazid. -- Bengoa JM, Bolt MJ, Rosenberg IH.