Bile Acid Sequestrant Drugs

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Bile Acid Sequestrant Drugs - Interactions and Warnings

Ingestion of cholestyramine significantly reduced the bioavailability of folic acid.
- Int J Vitam Nutr Res 1991;61(2):130-4 -- Bioavailability of folate following ingestion of cholestyramine in the rat. -- Hoppner K, Lampi B.

Combining psyllium with a submaximal dose of cholestyramine augmented the cholesterol-lowering action of the resin without effecting any marked change in the level of cholesterol absorption, except at the highest dose used. Psyllium, given either as a single agent or as an adjunct to treatment with cholestyramine, exerts a significant hypocholesterolemic effect by enhancing net negative sterol balance across the liver.
- Gastroenterology 1994 Aug;107(2):444-52 -- Psyllium augments the cholesterol-lowering action of cholestyramine in hamsters by enhancing sterol loss from the liver. -- Turley SD, Daggy BP, Dietschy JM.

Cholestyramine may deplete several vitamins and minerals. With prolonged treatment folate deficiency occurred, as evidenced by a fall in the mean serum folate concentration for patients on treatment for over one year; a corresponding lowering of red cell folate was also seen. There has been a significant decrease in the mean serum concentrations of vitamins A and E and of inorganic phosphorus over the first two years of treatment, although values remain within the normal range.
- Gut 1975 Feb;16(2):93-8 -- The effect of cholestyramine on intestinal absorption. -- West RJ, Lloyd JK.

last update: November 2008

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