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Cephalosporins - Interactions and Warnings

Parenteral nutrition may affect the patient's vitamin K status. This imposes a risk when using drugs that interfere with the vitamin K-dependent clotting factor synthesis, such as N-methyl-thiotetrazole-containing cephalosporins.
- Eur J Clin Nutr 1994 Jul;48(7):525-7 -- Vitamin K status and parenteral nutrition; the effect of Intralipid on plasma vitamin K1 levels. -- Drittij-Reijnders MJ, Sels JP, Rouflart M, Thijssen HH.

Hypoprothrombinemia is a serious adverse effect of antimicrobial therapy that occurs after administration of some second- and third-generation cephalosporins which contain the methyltetrazole-thiol group.
- J Clin Invest 1990 Nov;86(5):1589-94 -- Cephalosporin-induced alteration in hepatic glutathione redox state. A potential mechanism for inhibition of hepatic reduction of vitamin K1,2,3-epoxide in the rat. -- Mitchell MC, Mallat A, Lipsky JJ.

Cephalosporins can induce vitamin K deficiency.
- Drug Nutr Interact 1988;5(4):195-203 -- Drug and nutrient interactions in the elderly diabetic. -- Roe DA.

Please see: Antibiotics

last update: November 2008

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