cialis, Tadalafil, interactions

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Cialis (Tadalafil) - Interactions and Warnings


Tadalafil should not be administered in combination with organic nitrates.
- J Am Coll Cardiol. 2003 Nov 19;42(10):1855-60. -- Time course of the interaction between tadalafil and nitrates. -- Kloner RA, Hutter AM, Emmick JT, Mitchell MI, Denne J, Jackson G.

Drug-related adverse effects, with headache in up to 23% of patients (placebo, up to 17%), dyspepsia in up to 11% (placebo, up to 7%), back pain in up to 4.7% (placebo, 0%), and myalgia in up to 4.1% (placebo, up to 2.4%), were mostly mild to moderate.
- Int J Impot Res. 2002 Feb;14 Suppl 1:S57-64. -- IC351 (tadalafil, Cialis): update on clinical experience. -- Porst H.

Consult your doctor about all nonprescription and prescription medication you may use, especially any nitrate medications (e.g., nitroglycerin, isosorbide dinitrate), nitroprusside (any "nitric oxide donor" medicines), cimetidine, erythromycin, azole antifungals (e.g., itraconazole, ketoconazole), mibefradil, rifamycins (e.g., rifampin) or high blood pressure medicines.

Cialis is not recommended in patients who have suffered a heart attack or stroke within the last six months, or patients who have significantly low blood pressure, uncontrolled high blood pressure, unstable angina, severe liver impairment or retinitis pigmentosa (a rare eye disorder). Limit alcohol intake while using this drug.

You should not take Cialis if you take any medicines called nitrates or alpha blockers or if you have been told not to have sexual activity because of health problems.

Avoid use with medicines called alpha blockers. These include Hytrin® (terazosin), Flomax (tamsulosin), Cardura (doxazosin), Minipress (prazosin) or Uroxatral (alfuzosin). Other drugs to avoid during use are ritonavir (Norvir®) or indinavir (Crixivan®) ketoconazole or itraconazole (such as Nizoral or Sporanox), erythromycin and other medicines or treatments for erectile dysfunction.

Tell your physician if you are taking other products such as herbs or supplements to avoid possible interactions.





last update: November 2008



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