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Corticosteroids - Interactions and Warnings

Some corticosteroids such as prednisone and prednisolone do not readily cross the placenta and can be safely used during pregnancy as immunosuppressive drugs. Maternal complications related to corticosteroids may occur and close monitoring is therefore mandatory.
- Drug Saf 1998 Nov;19(5):389-410 -- Treatment of inflammatory rheumatic disorders in pregnancy: what are the safest treatment options? -- Ostensen M, Ramsey-Goldman R.

Bone loss in patients taking systemic corticosteroids. Patients being started on corticosteroids should receive prophylactic therapy with calcium and vitamin D.
- Cochrane Database Syst Rev 2000;(2):CD000952 -- Calcium and vitamin D for corticosteroid-induced osteoporosis. -- Homik J, Suarez-Almazor ME, Shea B, Cranney A, Wells G, Tugwell P.

Supplementation of vitamin D plus calcium is effective in corticosteroid-induced osteoporosis management.
- Clin Exp Rheumatol. 2000 Jan-Feb;18(1):3-4. -- Supplementation of vitamin D plus calcium is effective in corticosteroid-induced osteoporosis management. -- Bijlsma JW.

This study suggests that glycyrrhizin found in licorice increases the plasma prednisolone concentrations by inhibiting the metabolism of prednisolone and that it potentiates pharmacological effects of prednisolone.
- Endocrinol Jpn 1990 Jun;37(3):331-41 -- Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. -- Chen MF, Shimada F, Kato H, Yano S, Kanaoka M.

Data demonstrates that corticosteroid treatment increases chromium losses and that steroid-induced diabetes can be reversed by chromium supplementation.
- Diabet Med 1999 Feb;16(2):164-7 -- Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. -- Ravina A, Slezak L, Mirsky N, Bryden NA, Anderson RA.

Glucocorticoids elevate blood pressure.
- Biol Res Nurs 2002 Jul;4(1):16-21 -- Impaired vasodilation and nitric oxide synthase activity in glucocorticoid-induced hypertension. -- Mitchell BM, Webb RC.

Consult with your physician before using herbs or herbal products.

last update: November 2008

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