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Esomeprazole Magnesium - Interactions and Warnings
- Am J Health Syst Pharm 2002 Jul 15;59(14):1333-9 -- Esomeprazole: a clinical review. -- Johnson TJ, Hedge DD.
Gastric polyps and nodules may be found in children receiving long-term omeprazole therapy.
- J Pediatr Gastroenterol Nutr 2002 Nov;35(5):658-62 -- Gastric polyps and nodules in children receiving long-term omeprazole therapy. -- Pashankar DS, Israel DM.
Since intragastric pH will increase with esomeprazole treatment, it can be hypothesised that the absorption of digoxin and ketoconazole may be affected. In studies with diazepam, phenytoin and (R)-warfarin, it was shown that esomeprazole has the potential to interact with CYP2C19. Clarithromycin interacts with the metabolism of esomeprazole resulting in a doubling of the AUC of esomeprazole.
- Clin Pharmacokinet 2001;40(7):523-37 -- Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole. -- Andersson T, Hassan-Alin M, Hasselgren G, Rohss K.
Caution is indicated when certain drugs are co-prescribed. The incidence of clinically significant drug interactions increases proportionately with the number of drugs taken and with the age of the patient. The drug interaction with the greatest clinical importance is the reduction in benzodiazepine clearance by omeprazole.
- Eur J Gastroenterol Hepatol 2001 May;13(5):611-6 -- Proton pump inhibitors and their drug interactions: an evidence-based approach. -- Gerson LB, Triadafilopoulos G.
Nexium should not be used by children. Do not use if you are pregnant, planning to be or breastfeeding.
Please also see:Proton Pump Inhibitors