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Estrogen - Interactions and Warnings

The inhibition of bone resorption by ipriflavone (IP), an isoflavone derivative devoid of estrogenic properties but active in potentiating the effects of estrogen on bone tissue, has been shown in in vitro and in vivo studies and confirmed by clinical data.
- Calcif Tissue Int 1995 Feb;56(2):160-5 -- Interactions between ipriflavone and the estrogen receptor. -- Petilli M, Fiorelli G, Benvenuti S, Frediani U, Gori F, Brandi ML.

Many drugs alter hormonal status and these effects may produce marked deviations from the expected biodistribution. Diethylstilbestrol (stilboestrol), digitalis, gonadotrophins, phenothiazines and cimetidine all increase estrogen levels in high doses.
- Drug Saf 1993 Apr;8(4):280-94 -- Adverse reactions and drug interactions with radiopharmaceuticals. -- Sampson CB.

Estrogen may have any effect on levels of folic acid in the body.
- Am J Clin Nutr 2000 Nov;72(5):1156-63 -- Folate intake, lifestyle factors, and homocysteine concentrations in younger and older women. -- Rasmussen LB, Ovesen L, Bulow I, Knudsen N, Laurberg P, Perrild H.

Consult with your physician before using any herbs or herbal products.

Not recommended if you are pregnant, planning to be or breastfeeding.

Dietary boron supplementation enhanced the action of estrogen.
- Biol Trace Elem Res 2001 Summer;82(1-3):109-23 -- Dietary boron supplementation enhanced the action of estrogen, but not that of parathyroid hormone, to improve trabecular bone quality in ovariectomized rats. -- Sheng MH, Taper LJ, Veit H, Qian H, Ritchey SJ, Lau KH.

A study has raised concern about the risks associated with the use of estrogen and estrogen with progestin products, including increased risks for cardiovascular disease and breast cancer. As with all estrogens, the use of oral contraceptives is also associated with increased risks of some serious conditions, including heart attack, blood clots, stroke, liver tumors, and gallbladder disease. These risks are higher in women with underlying risk factors such as high blood pressure, high cholesterol and diabetes, and in those who smoke cigarettes.
- Women's Health Initiative (WHI) study, sponsored by the National Institutes of Health.

Consult with your physician before taking other medications to avoid potential adverse interactions.

See also: Hormone Replacement Therapy Side Effects

last update: November 2008

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