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Fenofibrate - Interactions and Warnings

It has been clearly established that lipid-lowering treatments such as fibrates can reduce cardiovascular events. Potentially more serious adverse effects, which are more clearly related to drug treatment and are probably dose-dependent, include elevations in hepatic transaminase levels and myopathy; however, these effects are uncommon and generally resolve rapidly when treatment is stopped. The risk of myopathy with fibrate treatment is increased in patients with renal impairment. Lipid-lowering drugs should be administered with extra caution to elderly patients.
- Drugs Aging 2001;18(9):665-83 -- How well tolerated are lipid-lowering drugs? -- Tomlinson B, Chan P, Lan W.

Fenofibrate, a phenoxyacid derivative, given at daily dose of 300mg during 1 year following a single blind design, lowered significantly serum triglycerides and total cholesterol in patients various types of hyperlipoproteinemias (IIa, IV, V), fibrate significantly reduced plasma uric acid. Side effects were few after prolonged treatment. Moderate and transient increases in creatine phosphokinase and glutamopyruvic transaminase values were shown in some patients. An interaction with oral anticoagulants was also observed.
- Artery 1980;7(1):73-82 -- Hypolipidemic and hypouricemic action of fenofibrate in various types of hyperlipoproteinemias. -- Harvengt C, Heller F, Desager JP.

last update: November 2008

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