Fluoroquinolones

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Fluoroquinolones - Interactions and Warnings


Drug interactions are limited; however, all fluoroquinolones interact with metal ion containing drugs (eg. antacids).
- Drugs 2002;62(1):13-59 -- A critical review of the fluoroquinolones: focus on respiratory infections. -- Zhanel GG, Ennis K, Vercaigne L, Walkty A, Gin AS, Embil J, Smith H, Hoban DJ.

Interactions between fluoroquinolones and drugs metabolised by the hepatic cytochrome P450 system affect the clearance of theophylline and caffeine.
- J Chemother 2000 Jan;12 Suppl 1:8-11 -- Safety of the new fluoroquinolones compared with ciprofloxacin. -- Ball P.

Quinolone absorption is significantly reduced by co-administration of antacids.
- J Chemother 2000 Jan;12 Suppl 1:8-11 -- Safety of the new fluoroquinolones compared with ciprofloxacin. -- Ball P.

Concurrent ingestion of iron causes marked decreases in the bioavailability of a number of drugs including ciprofloxacin. The major mechanism of these drug interactions is the formation of iron-drug complexes (chelation or binding of iron by the involved drug).
- Br J Clin Pharmacol 1991 Mar;31(3):251-5 -- Iron supplements: a common cause of drug interactions. -- Campbell NR, Hasinoff BB.





last update: November 2008



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