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Gabapentin - Interactions and Warnings

Abrupt discontinuation of Gabapentin can result in withdrawal symptoms. Clinicians are encouraged to taper Gabapentin dosage, especially when patients have taken high doses, and to warn patients of possible adverse effects of abruptly discontinuing Gabapentin themselves.
- Clin Neuropharmacol 2001 Jul-Aug;24(4):245-6 -- Gabapentin withdrawal syndrome. -- Norton JW.

Women of childbearing age face specific problems related to the epilepsy and to treatment with anticonvulsants. These include impaired fertility, failure of oral contraceptives and the risk of birth defects. Some new anticonvulsants may be suggested in preference to classical drugs to avoid these problems, but the human experience with newer anticonvulsants is still limited and, therefore, so is knowledge of the risk of congenital malformations in the offspring of mothers taking anticonvulsants. Psychiatric and behavioural changes frequently complicate treatment of patients with mental retardation. Some of the new anticonvulsants, in particular those affecting the gamma-aminobutyric acid (GABA) system such as vigabatrin, seem to exacerbate this problem and should be used with caution in these patients.
- Drugs 2000 Jul;60(1):23-33 -- Newer anticonvulsants: comparative review of drug interactions and adverse effects. -- Sabers A, Gram L.

The anticonvulsant gabapentin enhanced the acute analgesic effect of morphine. Furthermore, the plasma concentration of gabapentin was increased when morphine was administered concomitantly.
- Anesth Analg 2000 Jul;91(1):185-91 -- Gabapentin enhances the analgesic effect of morphine in healthy volunteers. -- Eckhardt K, Ammon S, Hofmann U, Riebe A, Gugeler N, Mikus G.

According to the criteria of causation it can be considered a possible adverse reaction caused by phenytoin related to incorporation of gabapentin. The mechanisms of this possible drug interaction are discussed, with emphasis on cytochrome P450 metabolism. The present case is a warning of the possible interaction of a drug (gabapentin) not contemplated when starting or when monitoring an antiepileptic treatment.
- Rev Neurol 2002 May 16;34(10):952-3 -- Possible gabapentin phenytoin interaction -- S nchez Romero A, Dur n Quintana JA, Garc a Delgado R, Margarito Rangel C, Poveda Andr s JL.

Consult with your physician if you are pregnant or taking other medications, herbs or vitamins.

last update: November 2008

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