Influenza Vaccine

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Influenza Vaccine - Interactions and Warnings

Interaction between a vaccine and a drug has been reported only with influenza vaccine and four drugs (aminopyrine, phenytoin sodium, theophylline, and warfarin sodium), and with BCG vaccine and theophylline. Some of these interactions still are unconfirmed.
- Drug Intell Clin Pharm 1984 Sep;18(9):697-700 -- Vaccine-drug interactions. -- D'Arcy PF.

Proposed interactions involving influenza vaccine with theophylline, warfarin, or phenytoin, and other combinations.
- DICP 1990 Feb;24(2):186-93 -- Drug interactions involving immunologic agents. Part II. Immunodiagnostic and other immunologic drug interactions. -- Grabenstein JD.

Less well recognized is the possibility that influenza vaccination may significantly increase carbamazepine blood levels. Our experience suggests that carbamazepine toxicity can result from influenza vaccination.
- Pediatr Neurol 2002 Jan;26(1):61-3 -- Carbamazepine toxicity after influenza vaccination. -- Robertson WC Jr.

last update: November 2008

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