Levitra, Vardenafil HCl, interactions

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Levitra (Vardenafil HCl) - Interactions and Warnings


Sildenafil, tadalafil, and vardenafil are all potent inhibitors of PDE5 and show the same mechanism of action, although they have some pharmacological differences that may translate into varying clinical effects.
- Can J Urol. 2003 Feb;10 Suppl 1:12-6. -- Pharmacology of phosphodiesterase 5 inhibitors. -- Carrier S.

Oral therapy for ED, namely the PDE5 inhibitors, is effective and safe in most cardiac and hypertensive patients. Organic nitrates such as nitroglycerin remain a contraindication to the concomitant use of these drugs.
- J Urol. 2003 Aug;170(2 Pt 2):S46-50; discussion S50. -- Erectile dysfunction in the cardiac patient: how common and should we treat? -- Kloner RA, Mullin SH, Shook T, Matthews R, Mayeda G, Burstein S, Peled H, Pollick C, Choudhary R, Rosen R, Padma-Nathan H.

The profile for this drug is similar to sildenafil (viagra). Caution should be exercised if you have heart related problems or are taking medication(s) for your heart. Numerous drugs can interact with drugs for erectile dysfunction by increasing plasma levels. This includes but is not limited to erythromycin, indinavir, ketoconazole, itraconazole and ritonavir.

There may be interaction with various herbs, especially ones that target the heart and circulatory system. Consult with your physician before taking herbs with this product.

Grapefruit juice interacts with Viagra and may interact adversely with Levitra as well.





last update: November 2008



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