Loop Diuretics

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Loop Diuretics - Interactions and Warnings

Calcium excretion is markedly reduced, but unlike other electrolyte disturbances from diuretics, this may be valuable: some suggest diuretics have an anti-osteoporotic action. Diuretics increase glucose and insulin resistance and should be used sparingly in diabetics.
- Eur Heart J 1992 Dec;13 Suppl G:96-103 -- Adverse reactions to diuretics. -- Prichard BN, Owens CW, Woolf AS.

One of the most common and serious side effects of diuretic therapy is in increased urinary loss of potassium. Another, although less well publicized, side effect of diuretic therapy is excessive urinary loss of magnesium. Loop-blocking diuretics cause major urinary losses of magnesium.
- Magnesium 1986;5(5-6):282-92 -- Magnesium and potassium-sparing diuretics. -- Ryan MP. These findings may explain the clinical observations of enhanced ototoxicity in patients administered amino-glycoside antibiotics concomitantly with loop diuretics.
- Ann Otol Rhinol Laryngol 1988 Jan-Feb;97(1):36-41 -- Potentiation of ototoxicity by glutathione depletion. -- Hoffman DW, Whitworth CA, Jones-King KL, Rybak LP.

last update: November 2008

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