Concurrent ingestion of iron causes marked decreases in the bioavailability of a number of drugs including methyldopa. The major mechanism of these drug interactions is the formation of iron-drug complexes (chelation or binding of iron by the involved drug).|
- Br J Clin Pharmacol 1991 Mar;31(3):251-5 -- Iron supplements: a common cause of drug interactions. -- Campbell NR, Hasinoff BB.
The major problems being hypotension associated in several patients with signs of cardiac or cerebral ischemia. Methyldopa therapy should be commenced cautiously in younger patients, in the non-obese, and in those with impairment of renal function as manifest by elevated blood urea nitrogen levels.
- Am Heart J 1978 Nov;96(5):572-9 -- Adverse reactions to methyldopa with particular reference to hypotension. -- Lawson DH, Gloss D, Jick H.
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