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Nitrofurantoin - Interactions and Warnings

Nitrofurantoin is contraindicated for patients with renal insufficiency.
- Am J Hosp Pharm 1979 Mar;36(3):342-51 -- Drug therapy reviews: nitrofurantoin. -- Gleckman R, Alvarez S, Joubert DW.

Administration of magnesium trisilicate with nitrofurantoin reduced the rate and extent of its excretion reflecting decrease in both rate and extent of absorption. The time during which the drug concentration in the urine was above the minimum effective concentration of 32 microgram/ml was also significantly reduced after administration of the antacid.
- Clin Pharmacol Ther 1979 Jun;25(6):857-63 -- Effect of magnesium trisilicate on nitrofurantoin absorption. -- Naggar VF, Khalil SA.

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last update: November 2008

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