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Nitroglycerin - Interactions and Warnings

Sildenafil is contraindicated in patients using long-acting nitrates or who may need to use short-acting nitrates, because the combination may cause a sharp fall of the blood pressure.
- Ned Tijdschr Geneeskd 2001 Jan 27;145(4):167-71 -- Drug treatment of erection disorders in patients with cardiovascular disease -- Meuleman EJ, Kingma JH.

Findings suggest that combination of sildenafil with nicorandil, as well as with nitroglycerin, potentiates the hypotensive response by augmentation of vasodilatation.
- Jpn J Pharmacol 2000 Nov;84(3):316-24 -- Hypotensive interaction of sildenafil and nicorandil in rats through the cGMP pathway but not by K(ATP) channel activation. -- Ishizuka N, Saito K, Akima M, Matsubara S, Saito M.

Consult with your physician before using herbs or herbal products.

last update: November 2008

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