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Penicillamine - Interactions and Warnings

Concurrent ingestion of iron causes marked decreases in the bioavailability of a number of drugs including penicillamine. The major mechanism of these drug interactions is the formation of iron-drug complexes (chelation or binding of iron by the involved drug).
- Br J Clin Pharmacol 1991 Mar;31(3):251-5 -- Iron supplements: a common cause of drug interactions. -- Campbell NR, Hasinoff BB.

Use caution with copper and zinc supplementation.
- Ann Pharmacother 1998 Jan;32(1):78-87 -- Zinc acetate treatment in Wilson's disease. -- Anderson LA, Hakojarvi SL, Boudreaux SK.

The absorption of vitamin B6 may be affected for those using penicillamine.
- J Nutr 1986 Jan;116(1):107-20 -- Gastrointestinal absorption of vitamin B-6 in the chicken (Gallus domesticus). -- Heard GS, Annison EF.

last update: November 2008

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