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Phenobarbital - Interactions and Warnings

Vitamin K deficiency may occur in pregnant women and the child after birth for women taking hepatic enzyme-inducing anti-epileptic drugs.
- Curr Treat Options Neurol 2002 Jan;4(1):31-40 -- Epilepsy in Pregnant Women. -- Bruno MK, Harden CL.

The combination of anitepileptic drugs and gabapentin generally results in synergistic or supraadditive interactions.
- Epilepsia 2002 Sep;43(9):956-63 -- Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis. -- Borowicz KK, Swiader M, Luszczki J, Czuczwar SJ.

Phenobarbital may reduce folic acid levels or absorption causing a deficiency.
- Clin Pharmacokinet 2002;41(8):559-79 -- Treatment of epilepsy in women of reproductive age: pharmacokinetic considerations. -- McAuley JW, Anderson GD.

Long term use may reduce calcium and vitamin D absorption.
- Clin Pharmacol Ther 1981 Oct;30(4):506-12 -- Long-term anticonvulsant therapy and intestinal calcium absorption. -- Wahl TO, Gobuty AH, Lukert BP.

last update: November 2008

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