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Phenothiazines - Interactions and Warnings

The treatment of two chlorpromazine-medicated chronic schizophrenics with cimetidine resulted in excessive sedation, which necessitated a reduction in chlorpromazine dosage. Eventual discontinuation of cimetidine therapy led to a return of schizophrenic symptoms, which responded to an increase in chlorpromazine dosage to previous levels.
- Br J Psychiatry 1989 Sep;155:413-5 -- Adverse interaction between cimetidine and chlorpromazine in two cases of chronic schizophrenia. -- Byrne A, O'Shea B.

Results indicate that a dietary constituent, the amino acid phenylalanine, can potentially exacerbate tardive dyskinesia symptoms in schizophrenic patients.
- Neuropsychopharmacology 1997 Feb;16(2):136-46 -- Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. -- Mosnik DM, Spring B, Rogers K, Baruah S.

Consult with your physician before using herbs or herbal products to avoid dangerous interactions.

last update: November 2008

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