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Primidone - Interactions and Warnings

Vitamin K deficiency may occur in pregnant women and the child after birth for women taking hepatic enzyme-inducing anti-epileptic drugs.
- Curr Treat Options Neurol 2002 Jan;4(1):31-40 -- Epilepsy in Pregnant Women. -- Bruno MK, Harden CL.

Antiepileptic drugs may cause a depletion of folic acid during long term use.
- J Neurol Sci 1997 Jan;145(1):109-12 -- Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy. -- Kishi T, Fujita N, Eguchi T, Ueda K.

Possible adverse effect on the metabolism of vitamin D and bone density.
- Clin Pharmacokinet 1982 Jan-Feb;7(1):57-84 -- Pharmacokinetic interactions with antiepileptic drugs. -- Perucca E.

Consult with your physician before using herbs to avoid dangerous interactions.

last update: November 2008

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