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Rifampin - Interactions and Warnings

Rifamycins [rifampicin (rifampin) more than rifabutin] induce cytochrome P450 enzymes and accelerate the metabolism of clarithromycin and HIV protease inhibitors. Conversely, clarithromycin inhibits these enzymes, resulting in increased rifabutin toxicity.
- Drug Saf 1999 Aug;21(2):137-52 -- Risk-benefit assessment of therapies for Mycobacterium avium complex infections. -- Griffith DE.

Combination treatment with rifampicin and isoniazid perturbs vitamin D metabolism, but less than might have been predicted from reports on each drug given alone. Nevertheless, tuberculous patients with already compromised calcium homeostasis receiving this combination of drugs should be carefully monitored.
- Clin Pharmacol Ther 1982 Oct;32(4):525-30 -- Effect of rifampicin and isoniazid on vitamin D metabolism. -- Brodie MJ, Boobis AR, Hillyard CJ, Abeyasekera G, Stevenson JC, MacIntyre I, Park BK.

Concomitant administration of atovaquone/proguanil is not recommended with rifampicin or rifabutin.
- Drugs 2003;63(6):597-623 -- Atovaquone/Proguanil : A Review of its Use for the Prophylaxis of Plasmodium falciparum Malaria. -- McKeage K, Scott L.

Please see: Antibiotics

last update: November 2008

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