Thiazide Diuretics

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Thiazide Diuretics - Interactions and Warnings

Calcium excretion is markedly reduced, but unlike other electrolyte disturbances from diuretics. Diuretics increase glucose and insulin resistance and should be used sparingly in diabetics.
- Eur Heart J 1992 Dec;13 Suppl G:96-103 -- Adverse reactions to diuretics. -- Prichard BN, Owens CW, Woolf AS.

Urinary zinc excretion was studied in a randomized trial in 9 patients during treatment with bendroflumethiazide, chlorthalidone and hydrochlorothiazide and in another 9 patients during treatment with bumetanide, furosemide and triamterene. During treatment with the thiazides, the zinc concentration rose by 30% and the total amount of zinc excretion increased by 60%. In contrast, during treatment with the loop-diuretics, urine zinc concentration diminished and the total amount of zinc excretion increased much less than during therapy with the thiazides.
- Acta Med Scand 1980;208(3):209-12 -- Urinary zinc excretion during treatment with different diuretics. -- Wester PO.

May cause magnesium deficiency and potassium deficiency.
- Acta Med Scand Suppl 1986;707:79-83 -- Potassium-sparing diuretics. -- Dyckner T, Wester PO. Possible dangerous interaction with licorice consumption.
- Ned Tijdschr Geneeskd 2001 Apr 14;145(15):744-7 -- Licorice hypertension also caused by licorice tea -- Brouwers AJ, van der Meulen J.

last update: November 2008

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