Tricyclic Antidepressants

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Tricyclic Antidepressants - Interactions and Warnings


Patients taking drugs with a narrow therapeutic index such as tricyclic antidepressants should be discouraged from using herbal products. All drugs with a narrow therapeutic index may either have increased adverse effects or be less effective when used in conjunction with herbal products.
- Crit Care Nurse 2002 Apr;22(2):22-8, 30, 32; quiz 34-5 -- Herbal remedies: drug-herb interactions. -- Kuhn MA.

Possible serotonin syndrome following the combined administration of clomipramine and alprazolam.
- J Clin Psychiatry 1995 Mar;56(3):122 -- Possible serotonin syndrome following the combined administration of clomipramine and alprazolam. -- Cano-Munoz JL, Montejo-Iglesias ML, Yanez-Saez RM, Galvez-Borrero IM.

Tricyclics were more likely than selective serotonin reuptake inhibitors/norepinephrine reuptake inhibitors to be associated with a reaction
- Psychosomatics 2002 May-Jun;43(3):228-33 -- Adverse reactions to antidepressants in consultation-liaison psychiatry inpatients. -- Smith GC, Clarke DM, Handrinos D, Trauer T.





last update: November 2008



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