valdecoxib, bextra, interaction

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Valdecoxib - Interactions and Warnings


Labeling has been updated with new warnings following postmarketing reports of serious adverse effects including life-threatening risks related to skin reactions - including Stevens Johnson Syndrome, and anaphylactoid reactions (serious allergic reactions). In addition, the labeling will state that the drug is contraindicated - not to be used - in patients allergic to sulfa containing products. As these reactions can be life threatening, people who start Bextra and experience a rash should discontinue the drug immediately.
- http://www.fda.gov/bbs/topics/ANSWERS/2002/ANS01170.html

The data indicate that administration of valdecoxib (Bextra) offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy.
- Eur J Gastroenterol Hepatol 2002 Oct;14(10):1101-11 -- Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. -- Sikes DH, Agrawal NM, Zhao WW, Kent JD, Recker DP, Verburg KM.

Valdecoxib (Bextra) has the potential to interact with several different prescription medications. The interactions may result in a serious adverse reaction. Consult with your physician and use caution if you are taking herbs or herbal products.

Valdecoxib (Bextra) has not been tested for safety in those under the age of eighteen.




Please also read about the interactions for Nonsteroidal Anti-Inflammatory Drugs for related information.





last update: November 2008



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