Zolmitriptan, zomig

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Zolmitriptan (Zomig) - Interactions and Warnings


The most commonly reported adverse events were taste disturbance, paresthesia, hyperesthesia, headache, and nasal/throat discomfort.
- J Clin Pharmacol 2002 Nov;42(11):1244-50 -- Pharmacokinetics, dose proportionality, and tolerability of single and repeat doses of a nasal spray formulation of zolmitriptan in healthy volunteers. -- Yates R, Nairn K, Dixon R, Kemp JV, Dane AL.

Complaints of subjective side effects usually increase according to an increase in dosage. The most frequent adverse effects were nausea and dizziness. Other discomforts are: dryness of the mouth, sensation of heat, paresthesia, asthenia, drowsiness, and dizziness. The sensation of heaviness, tightness or pressure of the throat and chest have also been reported.
- Neurologia 1998 Oct;13 Suppl 2:25-30 -- Safety profile of 311C90 (zolmitriptan) -- Morales Asin F.

Limit the daily administration of zolmitriptan with monoaminoxidase inhibitors (MAOI-A) since a possible increase of the levels of zolmitriptan and its metabolites may be detected in the presence of one (moclobemide).
- Neurologia 1998 Oct;13 Suppl 2:25-30 -- Safety profile of 311C90 (zolmitriptan) -- Morales Asin F.

The results suggest that propranolol inhibits biotransformation of zolmitriptan but with no change in the small pressor response to zolmitriptan.
- Br J Clin Pharmacol 1997 Dec;44(6):595-9 -- The interaction between propranolol and the novel antimigraine agent zolmitriptan (311C90). -- Peck RW, Seaber EJ, Dixon R, Gillotin CG, Weatherley BC, Layton G, Posner J.

All triptans narrow coronary arteries by 10% to 20% at clinical doses and should not be administered to patients with coronary or cerebrovascular disease. Some triptans have the potential for significant drug-drug interactions (sumatriptan, rizatriptan, and zomitriptan and monoamine oxidase inhibitors; rizatriptan and propanolol; zolmitriptan and cimetidine; and eletriptan and CYP3A4 metabolized medications and p-glycoprotein pump inhibitors).
- Med Clin North Am 2001 Jul;85(4):959-70 -- Safety and rational use of the triptans. -- Tepper SJ.

Interactions may occur with other prescription medications. Consult with your physician if you are pregnant or breastfeeding and before taking herbs or supplements.





last update: November 2008



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