What is Priftin used for? Priftin is an antibiotic used to
treat pulmonary tuberculosis (TB). Priftin must only be used in combination with at least
one other anti-TB drug prescribed for your condition. You must take Priftin twice a week
for 2 months with no less that 3 days (72 hours) between doses, plus other daily
medications as directed during this intensive phase of the treatment. It is critical that
you not miss even one dose of Priftin or your other medications during this 2-month
intensive phase of treatment to make sure that TB disappears from the saliva and to make
sure that TB does not return.
After the first 2 months, you must take
Priftin once a week in combination with at least another anti-TB drug prescribed for your
Experience using Priftin with HIV - positive patients is limited. If you are HIV
- positive, you may require more frequent doses; consult your health care provider.
Who should not take Priftin?
You should not take Priftin
if you have:
- a history of allergic reaction to any of the rifamycins (e.g., rifampin and
- a history of porphyria
General Precautions with Priftin:
- It is very important to take your medicines exactly as prescribed by your health
care provider for the entire time that you are being treated. It is especially important
not to skip doses. Otherwise, TB can return.
- If you begin having severe and/or constant diarrhea, stop taking Priftin
immediately and contact your health care provider for treatment.
- Priftin has been shown to interact with certain drugs (protease inhibitors) used
to treat HIV-infection.
- If you have a history of poor nutrition, alcoholism, diabetes, or you are a
teenager; your health care provider may want you to add vitamin B6 as a supplement
to your diet.
If you are in the late stages of pregnancy, your health care provider may check
your blood for clotting ability.
What should I tell my doctor or health care provider?
- Priftin may affect the reliability of birth control pills, so other methods of
birth control should be used while taking Priftin.
It is extremely important that you take your medicines as instructed for the
entire time you are being treated, and you must avoid missing doses of Priftin or any of
the other drugs you take in combination with Priftin during this time.
Tell your doctor or health care provider immediately if you experience any of
Tell your doctor or health care provider if you:
- Loss of appetite
- Feeling of general discomfort
- Dark colored urine
- Yellow skin or eyes
- Pain or swelling in your joints
- have a history of liver problems or abnormal liver test results, because anti-TB
medications can cause/create serious liver problems.
- are trying to become pregnant, are already pregnant, or are breast-feeding.
Because many other medications can interact with Priftin, review all medications
that you are taking with your health care provider, including those that you take without
What are some possible side effects of Priftin? (This is NOT
a complete list of side effects reported with Priftin. Your health care provider can
discuss with you a more complete list of side effects.)
Because Priftin is never taken alone, the following list of side effects may be shared
with any of the combination drug treatments used in clinical trials. They are:
- Blood in urine
- Skin breakouts
- Loss of appetite
- Loss of iron in the blood
- Joint pain
You may see a red-orange color change to your body fluids (e.g., urine, sweat,
spit, tears, and breast milk), or tissues (e.g., skin, teeth, and tongue).
If you wear contact lenses or
dentures, they may be permanently stained this red-orange
For more detailed information about Priftin, ask your health care provider.
Revised: 7/25/00, 9/4/01