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Brand Name: Rapamune®
Active Ingredient:   sirolimus
Strength(s): 1mg/ml, 1mg
Dosage Form(s):   Oral Solution, Tablet
Company Name:    Wyeth-Ayerst Laboratories
Availability:         Prescription only
*Dated Approved by FDA:   September 15, 1999
*Approval by FDA does not mean that the drug is available for consumers at this time.

What is Rapamune used for?

Rapamune is used together with cyclosporine and a steroid medication to prevent your body from rejecting a kidney transplant.  

Special Warnings with Rapamune:

In order to prevent transplant rejection, Rapamune suppresses the body’s immune system. This also decreases the ability of the body's immune system to protect against other diseases. While taking Rapamune there is an increased risk of infection and possible development of lymphoma (cancer of the immune system).

General Precautions with Rapamune: 

  • Rapamune can increase your blood cholesterol and triglyceride levels, which may require treatment.
  • Your doctor will monitor your kidney function and may adjust the dose of some of your immunosuppressant medications based on the test results.
  • Women of childbearing age should begin using an effective birth control method before starting to take Rapamune, and continue during Rapamune treatment and for 12 weeks after stopping Rapamune.
  • Before receiving any vaccinations, tell your doctor that you are taking Rapamune. Some vaccinations may be less effective during treatment with Rapamune, and certain vaccinations should be avoided.
  • Avoid sources of infection. Rapamune weakens your body's immune system and increases your risk of infection. Notify your doctor at the first sign of fever, chills, or a sore throat.

What should I tell my doctor or health care provider? 

  • Because many medications can interact with Rapamune, review ALL the medications that you are taking with your doctor, including those you take without a prescription.
  • Tell your doctor if you are trying to become pregnant, are already pregnant, or are breast-feeding.

What are some possible side effects of Rapamune? (This is NOT a complete list of side effects reported with Rapamune. Your health care provider can discuss with you a more complete list of side effects.)  

Rapamune is an immunosuppressant drug. Immunosuppressant drugs weaken your body's immune system and increase your risk of developing infection and possibly lymphoma. (See "Special Warnings").

Other side effects may include:

  • Increased cholesterol level
  • Increased lipid level
  • high blood pressure
  • Rash
  • acne
  • Anemia
  • Joint pain
  • Diarrhea
  • Decreased potassium level
  • Decreased blood platelets

For more detailed information about Rapamune, ask your health care provider.

Date Posted:  11/4/99
Updated: 8/30/00
Revised: 11/16/00


Back to Drug Side Effects

source: FDA

last update: December 2004

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