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Bitter Orange Side Effects, Interactions and Warnings

Bitter orange or synephrine, found in bitter orange, has been associated with adverse cardiovascular reactions. Based on the Naranjo probability scale, C. aurantium is possibly associated with this cardiovascular event.
- Ann Pharmacother. 2004 Mar 16 -- Possible Association of Acute Lateral-Wall Myocardial Infarction and Bitter Orange Supplement (May). -- Nykamp DL, Fackih MN, Compton AL.

Three studies reported increased metabolic rates when ingesting Citrus aurantium products.
- J Med. 2002;33(1-4):247-64. -- Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview. -- Preuss HG, DiFerdinando D, Bagchi M, Bagchi D.

Individuals with severe hypertension, tachyarrhythmias, and narrow-angle glaucoma and monoamine oxidase inhibitor recipients should avoid consumption. Persons taking decongestant-containing cold preparations should also refrain from intake.
- J Clin Pharmacol. 2001 Oct;41(10):1059-63. -- Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults. -- Penzak SR, Jann MW, Cold JA, Hon YY, Desai HD, Gurley BJ.

Bitter Orange may increase blood pressure and is considered a diuretic herb. There are also reports of it causing light sensitivity and skin irritation.

Bitter Orange can interact adversely with many types of prescription and over the counter medications. Do not use if you are pregnant or breastfeeding and do not give to children.

This information is not intended to be a substitute for professional medical advice. You should not use this material to diagnose or treat a health condition or disease without consulting with your healthcare provider.
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