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Guggul Side Effects, Interactions and Warnings

Guggul can have an effect on cholesterol levels in the body.
- Satyavati GV, Dwarakanath C, Tripathi SN. -- Experimental studies on the hypocholesterolemic effect of Commiphora mukul. Engl. (Guggul). -- Indian J Med Res. 1969 Oct;57(10):1950-62.

Guggul has anti-inflammatory properties.
- Arzneimittelforschung 1977 Jul;27(7):1455-7 -- Comparison of the anti-inflammatory activity of Commiphora mukul (an indigenous drug) with those of phenylbutazone and ibuprofen in experimental arthritis induced by mycobacterial adjuvant. --Sharma JN, Sharma JN.

Inhibits platelet aggregation.
- Mester L, Mester M, Nityanand S. -- Inhibition of platelet aggregation by "guggulu" steroids. Planta Med. 1979 Dec;37(4):367-9.

Concomitant oral administration with propranolol (Inderal) or diltiazem (Cardizem) can reduce their bioavailability and might reduce their therapeutic effects. Because of it’s action on the thyroid (guggulsterone has thyroid-stimulating activity) caution should be used when administering with thyroid drugs.
- J Assoc Physicians India 1994 Jun;42(6):454-5 -- Effect of gugulipid on bioavailability of diltiazem and propranolol. -- Dalvi SS, Nayak VK, Pohujani SM, Desai NK, Kshirsagar NA, Gupta KC.

Stimulates thyroid.
- Planta Med 1984 Feb;(1):78-80 -- Thyroid stimulating action of Z-guggulsterone obtained from Commiphora mukul. -- Tripathi YB, Malhotra OP, Tripathi SN.

Side effects of guggulipid were headache, mild nausea, eructation, and hiccup in a few patients.
- Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. -- Singh RB, et al. -- Cardiovasc Drugs Ther. 1994 Aug;8(4):659-64.

Other possible side effects include interactions with several prescription and over the counter drugs. Consult your physician before using especially if you are pregnant or nursing.

This information is not intended to be a substitute for professional medical advice. You should not use this material to diagnose or treat a health condition or disease without consulting with your healthcare provider.
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