Pine Bark

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Pine Bark Side Effects, Interactions and Warnings



  • Low acute and chronic toxicity with mild unwanted effects occurring in a small percentage of patients following oral administration. Dilation of the small blood vessels has been observed in patients with cardiovascular disease. The ability to inhibit angiotensin-converting enzyme is associated with a mild antihypertensive effect. May have an effect on blood thinning drugs.
    - Int J Clin Pharmacol Ther 2002 Apr;40(4):158-68 -- A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. -- Rohdewald P.

  • Displays greater biologic effects as a mixture than its purified components do individually indicating that the components interact synergistically. PYC has been reported to have a vasorelaxant activity, and the ability to enhance the microcirculation by increasing capillary permeability.
    - Free Radic Biol Med 1999 Sep;27(5-6):704-24 -- Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. -- Packer L, Rimbach G, Virgili F.







last update: March 2014



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