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Red Clover Side Effects, Interactions and Warnings

Fertility problems were noticed in cattle ingesting large amounts of red clover. It is believed that the estrogenic properties of the herb were responsible.
- Nord Vet Med. 1984 Mar-Apr;36(3-4):124-9. -- Plant oestrogens; the cause of decreased fertility in cows. A case report. -- Kallela K, Heinonen K, Saloniemi H.

Red clover is high in isoflavones and may have an effect on hormone levels in the body.
- J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):259-68. -- Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy. -- Beck V, Unterrieder E, Krenn L, Kubelka W, Jungbauer A.

Not recommended for use if you are pregnant or nursing.
- Nature. 1958 Oct 25;182(4643):1175. -- Reproductive disturbances of Romney ewe lambs grazed on red clover (Trifolium pratense) pastures. -- CH'ANG TS.

Use caution if you have any blood diseases as this herb may have an effect on blood sugar and insulin levels.
- Ann Nutr Metab. 2004 Sep-Oct;48(5):343-7. Epub 2004 Oct 20. -- Effects of Trifolium alexandrinum extracts on streptozotocin-induced diabetes in male rats. -- Amer M, El-Habibi el-S, El-Gendy A.

Red Clover reinforces warfarin action by heterogeneous mechanisms. It should thus not be used in patients on oral anticoagulant and/or antiplatelet therapy.
- Oral anticoagulants and medicinal plants. An emerging interaction -- Argento A, Tiraferri E, Marzaloni M. -- Ann Ital Med Int. 2000 Apr;15(2):139-43.

Red clover may increase the risk of bleeding or potentiate the effects of warfarin therapy.
- Am J Health Syst Pharm 2000 Jul 1;57(13):1221-7; quiz 1228-30 -- Potential interactions between alternative therapies and warfarin. -- Heck AM, DeWitt BA, Lukes AL.

last update: March 2009

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