HRT effects

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Side Effects of Hormone Replacement Therapy

When combined with synthetic progestins, both oral and transdermal/percutaneous estrogens use were associated with a significantly increased risk; for transdermal/percutaneous estrogens, this was the case even when exposure was less than 2 years. Our results suggest that, when combined with synthetic progestins, even short-term use of estrogens may increase breast cancer risk.
- Int J Cancer. 2005 Apr 10;114(3):448-54. Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort. Fournier A, Berrino F, Riboli E, Avenel V, Clavel-Chapelon F.

In contrast with the widely held belief among psychiatrists that progesterone depresses mood, neither of the progestogens we used in normal, nondepressed and nonanxious women showed this effect. Absence of an effect on mood was also found when the results of the two progestogens were combined.
- Menopause. 2002 Jul-Aug;9(4):253-63. Comparison of physical and emotional side effects of progesterone or medroxyprogesterone in early postmenopausal women.Cummings JA, Brizendine L.

Although parenteral administration of progesterone or low-dose progestins should in theory be associated with fewer side-effects than oral therapy, the long-term safety of the newer systems warrants further evaluation.
- Eur J Contracept Reprod Health Care. 2009 Apr;14(2):88-96. Parenteral administration of progestins for hormonal replacement therapy.Nath A, Sitruk-Ware R.

Some research studies show evidence that should deter women with heart disease or breast cancer from using hormone replacement therapy for menopause. Some of the possible side effects in the studies were breast tenderness, reduced insulin sensitivity, nausea and mood swings depending on the hormone used in HRT. Consult with your physician for more information.


last update: April 2009



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