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Milk Thistle Side Effects, Interactions and Warnings


Milk thistle increases bile flow and secretion which can result in loose stools.

If you think that you have a liver disorder, seek medical advice.

Can actually depress normal liver function if herb is not needed by the body.

Milk thistle has the potential to modulate cytochrome P450 activity and thus participate in interactions with conventional drugs.
- Xenobiotica 2002 Jun;32(6):451-78 -- Pharmacokinetic interactions between herbal remedies and medicinal drugs. -- Ioannides C.

Adverse and possibly violent reactions have been reported such as intermittent episodes of sweating, nausea, colicky abdominal pain, fluid diarrhoea, vomiting, weakness and collapse.
- Med J Aust 1999 Mar 1;170(5):218-9 -- An adverse reaction to the herbal medication milk thistle (Silybum marianum). Adverse Drug Reactions Advisory Committee.




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last update: October 2006



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