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Citrus Bioflavonoids Side Effects, Interactions and Warnings

The citrus bioflavonoid tangeretin neutralizes the beneficial tumor-suppressing effect of tamoxifen.
- Eur J Cancer 2000 Sep;36 Suppl 4:S73 -- Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer. -- Depypere HT, Bracke ME, Boterberg T, Mareel MM, Nuytinck M, Vennekens K, Serreyn R.

The pronounced interindividual variability of naringin kinetics provides a possible explanation for some of the apparently contradictory results of drug interaction studies with grapefruit and naringin.
- Clin Pharmacol Ther 1995 Oct;58(4):365-73 -- The fate of naringin in humans: a key to grapefruit juice-drug interactions? -- Fuhr U, Kummert AL.

These observations suggest that dietary citrus flavonoids may modulate colonic secretion, possibly through direct interaction with intracellular secretory pathways.
- J Nutr 1993 Feb;123(2):259-68 -- Citrus flavonoids stimulate secretion by human colonic T84 cells. -- Nguyen TD, Canada AT.

Nutrient Values
Fruits Vegetables Fish and Seafood Meat and Poultry Nuts

Nutrition Information

last update: March 2010

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