Citrus Bioflavonoids

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Citrus Bioflavonoids Side Effects, Interactions and Warnings



  • The citrus bioflavonoid tangeretin neutralizes the beneficial tumor-suppressing effect of tamoxifen.
    - Eur J Cancer 2000 Sep;36 Suppl 4:S73 -- Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer. -- Depypere HT, Bracke ME, Boterberg T, Mareel MM, Nuytinck M, Vennekens K, Serreyn R.

  • The pronounced interindividual variability of naringin kinetics provides a possible explanation for some of the apparently contradictory results of drug interaction studies with grapefruit and naringin.
    - Clin Pharmacol Ther 1995 Oct;58(4):365-73 -- The fate of naringin in humans: a key to grapefruit juice-drug interactions? -- Fuhr U, Kummert AL.

  • These observations suggest that dietary citrus flavonoids may modulate colonic secretion, possibly through direct interaction with intracellular secretory pathways.
    - J Nutr 1993 Feb;123(2):259-68 -- Citrus flavonoids stimulate secretion by human colonic T84 cells. -- Nguyen TD, Canada AT.




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  • last update: February 2014



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