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Vitamin B12 Side Effects, Interactions and Warnings

Those using oral hypoglycemics have diminished B12 absorption and low serum total vitamin B12.
- Diabetes Care 2000 Sep;23(9):1227-31 -- Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. -- Bauman WA, Shaw S, Jayatilleke E, Spungen AM, Herbert V.

An eruption resembling acne rosacea that was temporally associated with daily ingestion of high-dose B vitamin supplement. The eruption failed to respond to the usual treatment regimens for rosacea, but promptly improved when use of the vitamin supplement was discontinued.
- Cutis 1991 Aug;48(2):119-20 -- Acneiform eruption due to "megadose" vitamins B6 and B12. -- Sherertz EF.

Deterioration of acne vulgaris or eruption of an acneiform exanthema could be established during treatment with vitamin B6 and/or vitamin B12 in 14 patients. Females were by far the more frequently affected. The appearance of skin symptoms, even outside the age groups typically affected by acne vulgaris is characteristic. The clinical appearance of acneiform exanthema occurring during treatment with vitamin B6 or B12 consists of loosely disseminated small papules or papulopustules on the face (especially on the forehead and chin), on the upper parts of the back and chest and spreading to the upper arm. The pathogensis of the change is not yet certain. The acneiform rash generally fades within a short time after vitamin B6 or vitamin B12 treatment has been stopped.
- MMW Munch Med Wochenschr 1976 Feb 6;118(6):155-60 -- The problem of vitamin B6/B12 acne. A contribution on acne medicamentosa -- Braun-Falco O, Lincke H.

A potentially significant alteration of the absorption of cimetidine appears to exist with long-term use of vitamin B12.
- Q Rev Drug Metab Drug Interact 1984;5(1):25-51 -- Drug interactions involving cimetidine--mechanisms, documentation, implications. -- Greene W.

Use of other prescription medications may reduce levels of Vitamin B12 in the body.

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Nutrition Information

last update: March 2010

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