Vitamin K

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Vitamin K Side Effects, Interactions and Warnings



  • Patients should be cautioned concerning supplements of vitamin K used chronically or ingested in large quantities because it can interfere with oral anticoagulants.
    - J Am Diet Assoc 1995 May;95(5):580-4 -- Interaction of dietary factors with oral anticoagulants: review and applications. -- Harris JE.

  • Anaphylactoid reactions in patients receiving intravenously administered vitamin K have been reported. Use of intravenous vitamin K should be limited to patients with serious hemorrhage due to a coagulopathy that is secondary to a relative or absolute deficiency of vitamin K.
    - J Thromb Thrombolysis 2001 Apr;11(2):175-83 -- Anaphylactoid reactions to vitamin K. -- Fiore LD, Scola MA, Cantillon CE, Brophy MT.

  • There are three distinct types of cutaneous reactions to vitamin K1: localized eczematous, localized morphea-form, and, very rarely, diffuse maculopapular eruption. The eczematous type appears at the site of injection, the morphea-form type is a localized morphea-form patch that appears at the site of injection. Many of these reactions are very slow to clear up and some may persist as a chronic sclerodermoid change.
    - J Cutan Med Surg 2000 Jul;4(3):164-8 -- Cutaneous reactions associated with vitamin K1. -- Wilkins K, DeKoven J, Assaad D.




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  • last update: February 2014



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