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White Willow Side Effects, Interactions and Warnings



  • Upset stomach, nausea, or ringing in the ears may result. Lower the dosage or stop using white willow; call your doctor if symptoms persist.

  • Children under the age of 16 should not use white willow if they have a cold, influenza, or other viral illness. Using salicylates may cause Reye's syndrome, a potentially fatal condition.
    - Ann Pharmacother. 2005 Jul-Aug;39(7-8):1234-7. Epub 2005 May 31. Evaluation of presence of aspirin-related warnings with willow bark. Clauson KA, Santamarina ML, Buettner CM, Cauffield JS.

  • Individuals with ulcers or other stomach problems should use white willow with caution, because it can worsen stomach ills.

  • Do not mix white willow with other salicylates, such as aspirin or wintergreen oil, because of the potential for additive side effects.

  • May interfere with absorption of iron and other minerals when taken internally.

  • Incidences of hepatotoxicity and nephrotoxicity may be augmented by acetaminophen when concomitantly used with the potentially hepatotoxic herbs Echinacea and kava, and with herbs containing salicylate (willow, meadowsweet), respectively.
    - J Clin Pharm Ther 2002 Dec;27(6):391-401 -- Herbal medication: potential for adverse interactions with analgesic drugs. -- Abebe W.

  • A case of anaphylaxis resulting from the use of a willow bark-containing dietary supplement in a patient with a history of an aspirin allergy. The use of any willow bark-containing dietary supplement may present a risk of anaphylactic reaction to patients with a history of allergy to salicylates.
    - Ann Pharmacother. 2003 Jun;37(6):832-5. -- Anaphylactic reaction to a dietary supplement containing willow bark. -- Boullata JI, McDonnell PJ, Oliva CD.








last update: February 2014



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